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Yankees vs. Astros odds, prediction, line: 2022 MLB picks, Saturday, June 25 best bets from proven model

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American League contenders match up when the New York Yankees (52-19) and the Houston Astros (44-26) play early Saturday afternoon. These teams have split the first two games of the series, with the Astros securing a 3-1 win on Friday night. Gerrit Cole (6-1, 3.14 ERA) will be starting for the Yankees. Cristian Javier (4-3, 3.07 ERA) is on the mound for Houston.

The first pitch is set for 1:05 p.m. ET. New York is the -170 moneyline favorite (risk $170 to win $100) in the latest Astros vs. Yankees odds from Caesars Sportsbook, while Houston is a +150 underdog. The over-under for total runs scored is eight. Before making any Yankees vs. Astros picks, you need to see the MLB predictions and betting advice from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It’s on a 56-47 roll on top-rated MLB money-line picks through 11 weeks. Anybody who has followed it has seen profitable returns.

Now, the model has set its sights on Astros vs. Yankees, and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Yankees vs. Astros:

  • Yankees vs. Astros moneyline: New York -170, Houston +150
  • Yankees vs. Astros run-line: New York -1.5 (+125)
  • Yankees vs. Astros over-under: 8.5 runs
  • Yankees vs. Astros tickets: See tickets at StubHub
  • HOU: Astros are 14-3 in their last 17 during Game 3 of a series
  • NYY: Yankees are 10-2 in their last 12 vs. American League West

Featured Game | New York Yankees vs. Houston Astros

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